P-29: Study of The Environmental Effectsof EDCs, Perfluorooctanoic Acid and Diethylstilbestrol on Human ReproductiveParameters and Fertility Outcomes

Background: There is an important evidence that prolonged exposure to several endocrine disrupting chemicals (EDCs). These are persistent materials with unique environmental properties such as intake of contaminated food, water and air, irrespective of proximity to industries, which are suspected to have endocrine disrupting activities. Perflurooctanoic acid (PFOA) and diethylstilbestrol (EDCs) are risk factors for reduced fertility in men. Materials and Methods: Studies were found by searching the PubMed database for articles published up to 2013. The PubMed database on associations between PFOA and DES exposure men reproductive health are summarized and classified as fertility outcomes, transgenerational exposure and effects. Results: Many studies on EDCs such as PFOAs and DES are not always consistent in part due to limitations imposed by practical constraints. These results are discussed in the context of EDCs properties of PFOAs and DES substances that have been characterized in human studies. In order to make progress in this filed, we recommended taking advantage of monitoring and biobanks, including the development of appropriate biomarkers. Further human studies are warranted with particular focus on impaired fertility. They affect reproductive hormone levels, testicular volume, and semen quality. Each man provided a semen sample and a blood sample. Semen samples were analyzed for sperm concentration, total sperm count, motility, and morphology, and blood samples were used to measure reproductive hormones. Conclusion: The results suggest that exposure to PFOA and DES many affect human male semen quality and reproductive hormone levels, in other hand a detailed appraisal compounds specifically related to adverse reproductive outcomes is significant for prevention.